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KMID : 0545120130230070885
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Journal of Microbiology and Biotechnology
2013 Volume.23 No. 7 p.885 ~ p.896
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Recent Insights in the Removal of Klebseilla Pathogenicity Factors for the Industrial Production of 2,3-Butanediol
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Anupama Shrivastav
Lee Jin-Won
Kim Hae-Yeong
Kim Young-Rok
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Abstract
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2,3-Butanediol (2,3-BDO) has immense industrial applications. Recently, microbial fermentation has emerged as an alternative way to produce this industrially important chemical. Although 2,3-BDO is produced by several microorganisms, the Klebsiella genera has an excellent production compared with other 2,3-BDO-producing microorganisms. In order to produce 2,3- BDO on a large scale, the challenges of removing pathogenic factors from Klebsiella pneumoniae need to be addressed. K. pneumoniae produces a number of virulence factors that contribute to its pathogenesis, including lipopolysaccharides, capsules, fimbrial adhesins, etc. Removal of these pathogenic factors from 2,3-BDO-producing Klebsiella strains will result in avirulent strains for the safe, economic, and efficient production of 2,3-BDO. In this review, we summarize the current trends in 2,3-BDO production using K. pneumoniae and insights into the removal of its virulence factors for industrial applications.
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KEYWORD
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2,3-Butanediol, K. pneumoniae, capsule, fimbriae, lipopolysaccharide, pathogenic factors
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